Parathyroid Hormone Gene and Genes Involved in the Maintenance of Vitamin D Levels Association with Mandibular Retrognathism

In this study we evaluated whether single nucleotide polymorphisms (SNPs) in the genes encoding PTH, VDR, CYP24A1, and CYP27B1 were associated with mandibular retrognathism (MR). Samples from biologically-unrelated Brazilian patients receiving orthodontic treatment included study. Pre-orthodontic lateral cephalograms used to determine phenotype. Patients a retrognathic mandible selected as cases those an orthognathic controls. Genomic DNA was for genotyping analysis of SNPs PTH (rs694, rs6256, rs307247), VDR (rs7975232), CYP24A1 (rs464653), (rs927650). Chi-squared or Fisher’s tests compare genotype allele distribution among groups. Haplotype performed PTH. The established alpha p < 0.05. Multifactor dimensionality reduction (MDR) identify SNP–SNP interactions. A total 48 (22 males 26 females) MR 43 (17 controls included. linear angular measurements statistically different between (p 0.05). analysis, rs694, rs307247, rs464653 MDR analyses predicted best interaction model rs694–rs927650, followed by rs307247–rs464653–rs927650. Some haplotypes gene presented statistical significance. Our results suggest that are presence retrognathism.